| Protein name |
Alpha-lactalbumin |
| Host compatibility |
Komagatella phaffi (Pichia pastoris) |
| Yield |
0.056 g/L for human alpha-lactalbumin (Deng et al., 2022)
|
| Scale (in specific example) |
Lab scale in bioreactor (Deng et al., 2022)
|
| Biggest scale product has been develloped in this organism |
Patent filed by Perfect Day, so likely on pilot or industrial scale (Pandya et al., 2018)
|
| Regulatory status in Europe |
Not allowed |
| Regulatory status in other parts of the world |
No FDA GRAS approval in US, not allowed in Canada |
| Companies producing this protein in this organism |
Perfect Day (filed a patent)
|
| Extra/remark |
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| Publications/references |
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Deng, M., Lv, X., Liu, L., Li, J., Du, G., Chen, J., & Liu, Y. (2022). Efficient Bioproduction of Human Milk Alpha-Lactalbumin in Komagataella phaffii. Journal of Agricultural and Food Chemistry, 70(8), 2664–2672. https://doi.org/10.1021/acs.jafc.1c07908
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Pandya, R., Gandhi, P., Ji, S., Beauchamp, D., Hom, L., & Inc, P. D. (2018, March). US9924728B2 - Food compositions comprising one or both of recombinant beta-lactoglobulin protein and recombinant alpha-lactalbumin protein - Google Patents. https://patents.google.com/patent/US9924728B2/en
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Layman, D. K., Lönnerdal, B., & Fernstrom, J. D. (2018). Applications for α-lactalbumin in human nutrition. Nutrition Reviews, 76(6), 444–460. https://doi.org/10.1093/nutrit/nuy004
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Permyakov, E. A. (2020). α-Lactalbumin, Amazing Calcium-Binding Protein. Biomolecules, 10(9), 1210. https://doi.org/10.3390/biom10091210
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Piazenski, I. N., Candelário, J. P. M., Soccol, V. T., De Souza Vandenberghe, L. P., De Melo Pereira, G. V., & Soccol, C. R. (2024). From lab to table: The path of recombinant milk proteins in transforming dairy production. Trends in Food Science & Technology, 149, 104562. https://doi.org/10.1016/j.tifs.2024.104562
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Hochwallner, H., Schulmeister, U., Swoboda, I., Focke-Tejkl, M., Civaj, V., Balic, N., Nystrand, M., Härlin, A., Thalhamer, J., Scheiblhofer, S., Keller, W., Pavkov, T., Zafred, D., Niggemann, B., Quirce, S., Mari, A., Pauli, G., Ebner, C., Papadopoulos, N. G., . . . Spitzauer, S. (2010). Visualization of clustered IgE epitopes on α-lactalbumin. Journal of Allergy and Clinical Immunology, 125(6), 1279-1285.e9. https://doi.org/10.1016/j.jaci.2010.03.007
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